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Have you ever heard the phrase “aging like fine wine”? Or have you ever been told that you were aging like fine wine? There is more depth and power behind this sweet compliment on one’s beauty. The metaphor, ‘like fine wine’ , is popularly used to describe someone who looks physically better with age. But if we reflect deeper, we realize that the phrase can be associated with more than a physical attribute. It also relates to our internal journey as we unlock our fine wine, i

In a time when we are buried in false information, and personal opinions, we find ourselves digging harder for the truth. We must intensely, passionately, and persistently search for the truth. It is not enough to scratch the surface; one must dig deeper to find the truth. It is not enough to read a few articles and know the solution to the problem. It is not enough to be told something is good for you without analyzing the truth behind those claims. It is not enough to he

The biggest hurdles that exosomes face in the quest to be FDA-approved as a therapeutic are their heterogeneity and the lack of standardization. In other words, their different sizes and the different protocols that labs use to acquire and load the exosomes creates too much variability to be classified as a standard biologic that can be used in patients. Let’s break it down further… First, there is a size problem . One exosome, or ‘package’ might be large and fully loaded. An

If you ever need to determine if you are in the driving seat of your mind, try taking a journey on the subway trains. It sounds so simple, but it is a deceptive beast that truly challenges you and will quickly reveal to you who is in command. Imagine you are tired from a long day at work, but the train is delayed. You would probably feel broken down, frustrated and upset. Knees would bounce vigorously as anxiety increases. Patience and peace have left the moment it was announ

What happens when communication breaks down? We saw from Part 1 that the delivery mechanism is indeed a delicate process that is heavily reliant on the targeting abilities of exosomes and good communication. But similar to FedEx package deliveries, poor communication or specificity can lead to detrimental results. No matter how good the system is, we may have experienced at least one bad delivery. And that could be due to inclement weather, poor traffic and road conditions or

You have probably heard the age-old saying to be careful who you listen to and let rent space in your head . Like us, you may have understood the wisdom but failed to see how it connected. Well, many years later, we came to realize that the phrase stemmed from an anatomical truth – our ears are connected to our brainstems. Our brainstems are responsible for vital functions such as breathing, consciousness, sleep, heart rate, balance, coordination, and reflexes. Sounds travel

Ever wondered what exosomes are? They are nano-sized extracellular vesicles that are secreted by all living cells, playing an important role in cellular communication and delivery. Or more simply put, they are comparable to our modern FedEx delivery packages. Sent to a specific address, or target cell, they are packed with cargo consisting of proteins, lipids and genetic instructions (mRNA, miRNA). Exosomes are equipped with specific surface proteins, or ‘shipping labels’, th

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